Neurobiology of Disease Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline
نویسندگان
چکیده
Qiaoqiao Shi,1* Kenneth J. Colodner,2* Sarah B. Matousek,1† Katherine Merry,2† X Soyon Hong,2 Jessica E. Kenison,1 Jeffrey L. Frost,1 Kevin X. Le,1 Shaomin Li,1 X Jean-Cosme Dodart,3 Barbara J. Caldarone,3 Beth Stevens,2 and X Cynthia A. Lemere1 1Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, 2Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and 3Harvard NeuroDiscovery Center NeuroBehavior Laboratory Core, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115
منابع مشابه
Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline.
The complement system is part of the innate immune response responsible for removing pathogens and cellular debris, in addition to helping to refine CNS neuronal connections via microglia-mediated pruning of inappropriate synapses during brain development. However, less is known about the role of complement during normal aging. Here, we studied the role of the central complement component, C3, ...
متن کاملAlterations in adult hippocampal neurogenesis, aberrant protein s-nitrosylation, and associated spatial memory loss in streptozotocin-induced diabetes mellitus type 2 mice
Objective(s): Epidemiological and biochemical studies conducted over the past two decades have established a strong link between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). However, the exact mechanisms through which aberrations in insulin signaling associated with T2DM contribute to cognitive decline are not yet known. Materials and Methods: In an effort to explore possible m...
متن کاملCd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium–choroid with age
Dysregulation of the complement system has been implicated in the pathogenesis of age-related macular degeneration. To investigate consequences of altered complement regulation in the eye with age, we examined Cd59a complement regulator deficient (Cd59a(-/-)) mice between 4 and 15 months. In vivo imaging revealed an increased age-related accumulation of autofluorescent spots in Cd59a(-/-) mice,...
متن کاملA dramatic increase of C1q protein in the CNS during normal aging.
The decline of cognitive function has emerged as one of the greatest health threats of old age. Age-related cognitive decline is caused by an impacted neuronal circuitry, yet the molecular mechanisms responsible are unknown. C1q, the initiating protein of the classical complement cascade and powerful effector of the peripheral immune response, mediates synapse elimination in the developing CNS....
متن کاملC3 and C4 Complement Levels in Iron Deficiency Anemia
Background and Objectives: Complement proteins are some of the most important plasma proteins of the innate immune system. Impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. This study was conducted to show whether serum C3 and C4 complement change in adult nonpregnant female with iron deficient anemia or ...
متن کامل